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Author

Kang-Yi Hu

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Review Open access Aug 2026

Lactate-driven lactylation reprograms chondrocyte fate and joint inflammation in osteoarthritis: linking metabolism with epigenetic regulation

The sustained progression of osteoarthritis (OA) arises not only from mechanical injury and inflammatory stimulation but also from the gradual loss of chondrocyte homeostatic identity. However, a unifying mechanism explaining how metabolic abnormalities within the joint microenvironment are converted into relatively st...

Xin-Yu Liu, Kang-Yi Hu, Deng-Yan Bai · 0 citations
Review Open access Aug 2026

Synovial immune control failure in osteoarthritis: from maintenance of tissue homeostasis to inflammatory niche formation

Osteoarthritis (OA) is a whole-joint disease involving cartilage, synovium, subchondral bone, and neurovascular structures. Synovitis, damage-associated molecular patterns, and interactions between macrophages and fibroblast-like synoviocytes have been widely studied. However, a tissue-level explanation is still lackin...

Kang-Yi Hu, Yong-Jia Song, Jia-Xing Pan et al. · 0 citations

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