TMEM175: Lysosomal Ion Channel Physiology, Therapeutic Potential, and Emerging Pharmacology.
Transmembrane protein 175 (TMEM175) is a lysosomal cation channel that has emerged as a promising drug target for Parkinson's disease (PD). Genetic and functional studies linking TMEM175 loss-of-function variants to increased PD risk, lysosomal dysfunction, and α-synuclein accumulation have generated considerable inter...