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Kang-Jun Li

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Review Open access Oct 2026

TMEM175: Lysosomal Ion Channel Physiology, Therapeutic Potential, and Emerging Pharmacology.

Transmembrane protein 175 (TMEM175) is a lysosomal cation channel that has emerged as a promising drug target for Parkinson's disease (PD). Genetic and functional studies linking TMEM175 loss-of-function variants to increased PD risk, lysosomal dysfunction, and α-synuclein accumulation have generated considerable inter...

Kang-Jun Li, Samantha D. Le, J. Denton · 0 citations

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