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Author

Kanak Parmar

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Open access Oct 2026

Plasma nucleosome profiling reports on tumor burden and molecular subtypes in small cell lung cancer

BACKGROUND Small-cell lung cancer (SCLC) is an aggressive malignancy with a poor prognosis and marked transcriptional heterogeneity that may drive distinct therapeutic vulnerabilities. Clinical translation of molecular subtyping has been limited by restricted access to tumor biopsies, particularly at relapse. METHODS W...

Gavriel Fialkoff, N. Takahashi, Israa Sharkia et al. · 0 citations
Open access Aug 2026

Spatially Organized Tertiary Lymphoid Structures Emerge in Small Cell Lung Cancer and Associate with Improved Survival

Tertiary lymphoid structures (TLS) are ectopic immune aggregates associated with improved prognosis and response to immunotherapy in multiple solid tumors. However, their presence, spatial organization, and functional relevance in small cell lung cancer (SCLC), a malignancy characterized by profound immune evasion, rem...

Yingying Cao, M. Nirula, Paul Mallory et al. · 0 citations

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