Review
Open access
Sep 2026
Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development.
This review highlights recent clinical advances-including motixafortide and zilucoplan-and examines how UAAs are deployed to optimize drug-like characteristics across diverse therapeutic areas, and discusses emerging strategies, illustrative case studies, and design principles that collectively support the development...
Krishna K. Sharma, K. Sharma, Anku Sharma et al.
· Angewandte Chemie · 0 citations