Teeter-Totter-Like Redistribution of Switch I: Integrating Simulation and Experiment to Uncover the Molecular Basis of Oncogenic Rac1Mutations.
Rac1 is a small GTPase of the Rho family. It is a central regulator of cytoskeletal remodeling, cell adhesion, migration, and secretion. Dysregulation of Rac1 activity drives tumorigenesis, with the cancer-associated P29S mutation ranking as the third most frequently mutated proto-oncogene in sun-exposed melanoma. P29S...