Author

Kaitlyn Manzer

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#protein folding Open access Oct 2026

Functional genetics reveals a role for the proteasome in regulating centromere assembly

Centromeres link chromosomes to spindle microtubules to direct their segregation during mitosis. The vertebrate centromere is built on two critical DNA-binding proteins, the histone H3-variant CENP-A and histone fold protein CENP-T. CENP-T is a potent scaffold for kinetochore assembly, such that concentrating it at ect...

Océane Marescal, Kuan-Chung Su, Matteo Di Bernardo et al. · bioRxiv · 0 citations

Open access Jul 2026

Systematic functional genetic analysis of cell-substrate adhesion

This work defines the requirements for cell-substrate adhesion in cultured human cells using orthogonal, large-scale functional genetic approaches and identifies established and uncharacterized regulators of adhesion, including genes involved in mitosis, focal adhesions, actin regulation, and membrane trafficking.

Kaitlyn Manzer, Kuan-Chung Su, Matteo Di Bernardo et al. · bioRxiv · 0 citations