Kai P. Atlass

A metabolic-epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition.

Cardiac regeneration is limited in the adult mammalian heart because of restricted cardiomyocyte proliferation and persistent fibrosis. We previously demonstrated that transient pharmacological inhibition of succinate dehydrogenase (SDH) with malonate promotes regeneration after myocardial infarction. Here, we integrat...