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Review Open access Oct 2026

Deep brain stimulation and spinal cord stimulation for chronic disorders of consciousness: a decade of clinical evidence, mechanistic insights, and critical appraisal

Deep brain stimulation (DBS) and spinal cord stimulation (SCS) have been investigated for over four decades as neuromodulatory treatments for chronic disorders of consciousness (DOC), including the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), for which no disease-...

Dong-Sheng Liu, Kai-Wai Yang, Jian-Lei An et al. · 0 citations
Sep 2026

H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids.

Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...

Lu-Yang Xie, Zhuan-Xin Jiang, Hang Zhou et al. · 1 citation

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