Herein, we disclose a microflow system-mediated oxidative cyclization process catalyzed by multicopper oxidase, employing 2,3-dihydroxybenzoic acid and a range of substituted tetrahydrocarbazoles to afford structurally complex isochromanoindolenines. The reaction proceeds under mild conditions without the need for ex...
Shu-Zhan Wang, Qian-Xi Zhou, Xue-Ming Wang et al.· ACS Sustainable Chemistry &a...· 0 citations
Sulfur-containing compounds, particularly thioethers, are of significant value in the pharmaceutical, agrochemical, and functional materials industries. Traditional methods for constructing C-S bonds are often constrained by harsh reaction conditions and limited substrate scope. Alcohols represent the most abundant and...
Yang Zeng, Yujian Pang, Dan-Dan Fan et al.· Organic and biomolecular che...· 0 citations
Axially chiral biaryl dimethanols are ubiquitous and multifunctional intermediates for the synthesis of valuable atropisomeric molecules in advanced materials, drugs, natural products, and organocatalysts. Despite their broad synthetic utility, direct enantiodivergent catalytic access to this specific class of compou...
Jie Chen, Zhuoting Peng, Xiaolong Gao et al.· ACS Catalysis· 0 citations
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