Artesunate reverses alveolar macrophage immunometabolic collapse and prevents breast cancer lung metastasis via the SREBP1- and FATP4-dependent fatty acid axis.
BACKGROUND Alveolar macrophages (AMs) are critical sentinels of the lung microenvironment, however, the metabolic mechanisms driving their functional reprogramming within the breast cancer pulmonary pre-metastatic niche (PMN) remain poorly defined. PURPOSE This study aimed to elucidate the metabolic-immune crosstalk...