K. Z. Lin

Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq

ScDRS-FM is introduced, a method that disentangles causal from tagging disease associations at single-cell resolution by jointly modeling correlated cell populations to assess conditional polygenic enrichment relative to other cell populations in the dataset; scDRS-FM further leverages single-cell denoising to improve...