Author

K. Ying

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Open access Sep 2026

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

Drugs for aging-related diseases may modulate aging itself, but standard clinical trial designs cannot detect such effects. Aging clocks could close this gap, but epigenetic models often yield inconsistent, hard-to-interpret results. In contrast, proteomic clocks, by tracking the immediate effectors of biological chang...

Alex Zhavoronkov, F. Galkin, Shan Chen et al. · Nature Biotechnology · 1 citation

Open access Aug 2026

Novel Exploratory Transcriptomic Candidates as Biomarkers and Cancer Hallmark Fingerprints for Ovarian Endometroid and Clear Cell Carcinomas in Women

Background: Endometriosis-associated ovarian cancers (EAOCs), encompassing clear cell (CC) and endometrioid carcinomas (EC), constitute distinct biological entities yet lack robust biomarkers for precise classification, prognostication, and therapeutic decision-making in women. Therefore, we aimed to describe novel bio...

Pawel Kordowitzki, K. Ying · Antioxidants · 0 citations

#computer vision Oct 2025

ECloudGen: leveraging electron clouds as a latent variable to scale up structure-based molecular design

This study presents ECloudGen, which uses latent diffusion to generate electron clouds from protein pockets and decodes them into molecules, and adopts two-stage training, which expands the chemical space accessible to generative drug design.

Odin Zhang, Jieyu Jin, Zhenxing Wu et al. · Nature Computational Science · 4 citations