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The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing
A specialized cortical niche is identified that coordinates immune and stromal cells to drive early osteoclast formation during fracture healing and shows that aging primarily impairs this supportive microenvironment rather than the cells themselves.
Surface-engineered WE43 magnesium implants promote bone repair and reshape the peri-implant immune microenvironment.
PEO is associated with a less pro-inflammatory peri-implant immune profile at day 28, and improved bone healing parameters, which inform the design of immunomodulatory, degradable implants to improve bone healing.