Open access
Aug 2026
Structural and mechanistic analyses reveal collaborative regulation of HSF1 by the Hsp70-Hsp90 chaperone systems
A FRET-based approach to simultaneously monitor HSF1 conformational change and oligomeric state throughout activation and inactivation is developed and previously contradictory view on Hsp90’s role in HSF1 regulation is unify.
T. Owens, K. Schaefer, Trenton M. Peters-Clarke et al.
· bioRxiv · 0 citations