Dictyostelium discoideum is a model organism used to investigate a wide array of biological processes including chemotaxis, cell motility, phagocytosis, multicellular development, and autophagy. Many of its genes have human orthologs implicated in disease, making it a useful model organism for studying conditions rangi...
Maddox Mendieta, R. Dodson, S. Basu et al.· Research Square· 0 citations
Analysis of SCA48-associated variants spanning the TPR and U-box domains indicates that SCA48 results from domain-specific disruption of CHIP's dual functions, producing varying degrees of CHIP insufficiency and/or gain-of-toxic effects that together contribute to the phenotypic diversity observed across patients.
S. Altinok, E. Paulakonis, Michael F. Almeida et al.· Journal of Biological Chemis...· 0 citations
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