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K. Scaglione

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Review Open access Sep 2026

dictyBase 2026: a reimplementation of the Dictyostelium model organism database on minimal infrastructure

Dictyostelium discoideum is a model organism used to investigate a wide array of biological processes including chemotaxis, cell motility, phagocytosis, multicellular development, and autophagy. Many of its genes have human orthologs implicated in disease, making it a useful model organism for studying conditions rangi...

Maddox Mendieta, R. Dodson, S. Basu et al. · 0 citations
Open access Aug 2026

Domain-dependent uncoupling of the co-chaperone and E3 ubiquitin ligase CHIP underlies heterogeneity in spinocerebellar ataxia 48

Analysis of SCA48-associated variants spanning the TPR and U-box domains indicates that SCA48 results from domain-specific disruption of CHIP's dual functions, producing varying degrees of CHIP insufficiency and/or gain-of-toxic effects that together contribute to the phenotypic diversity observed across patients.

S. Altinok, E. Paulakonis, Michael F. Almeida et al. · 0 citations

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