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Author

K. Satoh

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Open access Sep 2026

Detection of α-synuclein seeding activity in tear fluid as a candidate biomarker for Parkinson's disease

Background Parkinson's disease (PD) is an α-synucleinopathy, and pathological α-synuclein (α-Syn) is detectable in peripheral tissues and fluids. However, the diagnostic utility of tear fluid as a minimally invasive source for α-Syn seed detection remains unclear. We aimed to detect α-Syn seeds in tear fluid and evalua...

Asako Kakimoto, K. Satoh, Tomoko Tsukahara-Kawamura et al. · 0 citations
Open access Aug 2026

Detection of TDP-43 Proteinopathies in Brain and Cerebrospinal Fluid Using Seed Amplification Assay

Misfolded TAR DNA-binding protein 43 (TDP-43) is the primary pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While seed amplification assays (SAAs), such as real-time quaking-induced conversion (RT-QuIC), have shown promise in detecting misfolded TDP-43 in cere...

K. Satoh, M. Shimamura, Takeshi Fujimoto et al. · 0 citations
Review Open access Aug 2026

Prion-like Protein TDP-43: Mechanisms, Diagnosis, and Therapeutic Prospects

This review synthesizes how decoding the structural and RNA-metabolic complexities of TDP-43 is paving a promising pathway from bench to bedside, while critically discussing current translational limitations.

M. Shimamura, K. Satoh · 0 citations

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