Pyridine-core scaffolds suppress A549 lung cancer cell progression: Evaluation of the antiproliferative activity, apoptosis, ROS generation, clonogenic suppression, and EGFR expression.
Targeting the epidermal growth factor receptor (EGFR) remains a proven strategy for the treatment of lung adenocarcinoma; however, acquired drug resistance and suboptimal long-term efficacy of the currently available EGFR inhibitors spurred the pursuit of new EGFR-targeted molecules. Hence, a series of pyridine-cored d...