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Author

K. Rottner

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Open access Sep 2026

Dynamic protrusions mediate crawling motility in Asgard archaea.

Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2. Asgard archaea, which are considered the closest known prokaryotic relatives of eukaryotes, potentially encode these functions within their large set of 'euka...

Philipp Radler, Tobias Viehboeck, Zhen-Hao Luo et al. · 0 citations
Open access Sep 2026

Profilin promotes lamellipodium protrusion by tuning the antagonistic activities of capping protein and VASP

Cell migration frequently employs protrusions termed lamellipodia, constituting the prime model system for generation of branched actin filament networks. Here we utilize genome editing to explore the functional connections between the actin monomer-binding protein profilin (Pfn), the filament nucleating Arp2/3 complex...

Yu-Bo Tang, M. Schaks, Xin-Qi Jiang et al. · 0 citations
Open access Oct 2026

Daam-, FMNL-, and mDia-family formins jointly regulate cortical actin dynamics in melanoma cells

The actin-rich cell cortex is a viscoelastic structure essential for processes such as cell migration and division, yet the full spectrum of actin assembly factors that build and regulate the cortex in mammalian cells remains incompletely defined. While the Arp2/3 complex generates actin networks mostly comprising shor...

Thomas Kaufmann, Jonas Scholz, Á. Csiszár et al. · 0 citations

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