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Open access Oct 2026

A temperate phage acts as a symbiotic fitness enhancer for UPEC but surrenders to combination therapy through lysogeny suppression

ABSTRACT Temperate phages are increasingly recognized as key drivers of bacterial evolution. Here, we isolated a myoviral prophage, vB_EcoM_P899, from a clinical uropathogenic Escherichia coli (UPEC) isolate and characterized how lysogenization shapes host biology. Lysogenization significantly enhanced biofilm formatio...

Bo Yan, Can Yan, Qing-Wen Li et al. · 0 citations
Open access Oct 2026

PhageHost-GNN: novelty-aware and locally adaptable strain-level Klebsiella-phage prediction

Interest in bacteriophages as alternative treatments for bacterial infections has grown amid the ongoing crisis of multidrug resistance. However, their narrow host range makes it labor-intensive to identify matching phages for bacterial isolates using conventional experimental methods. Although existing computational m...

Biffon Manyura Momanyi, K. Qin, Kai Zhou et al. · 0 citations

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