Open access
Sep 2026
Design, synthesis, SAR, in silico and in vitro evaluation of 1, 3, 4-oxadiazole derivatives against breast cancer
R3 emerges as a promising VEGFR2-targeted lead for further breast cancer drug development and structure-activity relationship analysis indicated that meta and para chloro substitutions enhance binding and activity, while ortho substitution reduces affinity due to steric effects.
Rekha Singh, B. Matore, A. Murmu et al.
· Discover Chemistry · 0 citations