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Author

K. Nogami

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Open access Sep 2026

FRONTIER5: Safety and patient experience of a direct switch from emicizumab to denecimig (Mim8) in patients with haemophilia A with or without inhibitors.

BACKGROUND Denecimig (Mim8) is an activated factor VIII mimetic, fully human, bispecific IgG4 antibody in development for subcutaneous prophylaxis in patients with haemophilia A (HA) with/without inhibitors. OBJECTIVE To evaluate the safety and patient experience of a direct switch from emicizumab to denecimig prophy...

Cédric Hermans, Gary Benson, D. Matino et al. · 1 citation
Jul 2026

Extended Half-Life Recombinant Factor VIII Conjugated with Modifying Substances Does Not Affect Fibrin Clot Formation or Stability in Haemophilia A Blood Samples.

Direct modification by PEGylation or IgG-Fc fusion to impart EHL characteristics preserves the functional properties of native FVIII, suggesting that PEGylation or Fc fusion do not impair its functional properties related to fibrin clot formation and stability.

N. Shimonishi, K. Nogami · 0 citations

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