Network-integrated Virtual Screening Identifies HIF-1α Targeting Phytochemicals from Ajuga decumbens
Background: Tumour hypoxia is a critical hallmark of cancer progression, contributing to metastasis, therapeutic resistance, and poor clinical outcomes. Hypoxia-inducible factor-1 alpha (HIF-1α) regulates cellular adaptation to hypoxia by modulating angiogenesis, metabolism, and survival. Targeting HIF-1α represents a...