Kuniyasu Niizuma

RNA–Protein Dynamics of the Segmentation Clock and Its Implications in Developmental Disorders

Somitogenesis is orchestrated by the segmentation clock, a highly conserved developmental oscillator that generates periodic gene expression waves to establish precise somite boundaries along the vertebrate body axis. While transcriptional feedback circuits and signaling gradients are recognized as central determinants...

[Emerging Therapeutic Strategies for Central Nervous System Regeneration].

MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease

Overall, MA-5 suppresses neuroinflammation and reverses accelerated transcriptomic aging, supporting its potential as a therapeutic strategy for GD and other lysosomal storage disorders, as well as for diseases characterized by mitochondrial dysfunction, chronic inflammation, and pathological accumulation.

Transcriptome-wide splicing analysis reveals HuR-regulated post-transcriptional programs in osteocytes

Findings support HuR’s role as a key post-transcriptional regulator of osteocyte metabolic adaptation under high-glucose stress, with potential implications for hyperglycemic bone fragility.