Open access
Aug 2026
Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models
In adipose-derived mesenchymal stem cells exposed to metabolic stimulations, CASTIE increased eGene discovery by 36-92% across cell populations and identified stimulation-dependent regulatory effects at metabolic trait loci, revealing disease-relevant regulatory variation beyond static eQTL mapping.
Yijia Christiana Liu, A. Cuomo, Yi Huang et al.
· medRxiv · 0 citations