Open access
Oct 2026
Doxorubicin Encapsulation in D-α-Tocopherol Succinate-Functionalized β-Cyclodextrin Enhances Intracellular Retention and Cytotoxicity in a Chemoresistant T-ALL Model
Therapeutic resistance remains a major limitation in T-cell acute lymphoblastic leukemia (T-ALL) and can reduce the efficacy of chemotherapeutic agents, including doxorubicin (DOXO). Since intracellular drug accumulation and retention are important determinants of DOXO activity, we evaluated whether its encapsulation i...
Miguel Olivas-Aguirre, Laura Cecilia Ramírez-Oseguera, Alondra Montañez Rios et al.
· Lymphatics · 0 citations