Author

K. Maeshima

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Review Sep 2026

Mitotic chromosomes: from the chromosome scaffold model to condensins and physical forces.

Mitotic chromosome organization and assembly remain fundamental questions in genetics. Since the chromosome scaffold model proposed in 1977 highlighted the role of nonhistone proteins in determining chromosome shape and size, key nonhistone proteins, including condensins and topoisomerase IIα (topoIIα), have been shown...

K. Maeshima, Masa A. Shimazoe, Sachiko Tamura · Trends in Genetics · 0 citations

Open access Sep 2026

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. Here, to address this question, we combine...

Masa A. Shimazoe, Shiori Iida, Katsuhiko Minami et al. · Nature Genetics · 12 citations