K. Maeda

Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation

Introduction CD6 is an immunological synapse-associated receptor that integrates adhesive and signaling cues to shape T-cell activation. We previously showed that, in CD6-humanized mice, the anti-human CD6 monoclonal antibody UMCD6 suppresses disease severity and Th1/Th17 responses in models of autoimmunity, but its me...