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Author

K. Lin

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Open access Aug 2026

Reclassification of Genetic Variants in Patients with Hypertrophic Cardiomyopathy from the Sarcomeric Human Cardiomyopathy Registry (SHaRe)

Background: Genetic testing is a Class I recommendation for patients with hypertrophic cardiomyopathy (HCM). As knowledge and frameworks continue to evolve, genetic variant classifications may change with new evidence over time. Classifications rely on evidence sought from publicly available case data, improved classif...

S. Hespe, G. Powell, L. Catto et al. · 0 citations
Open access Jul 2026

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

It is found that a subcellular signaling pathway dysregulated in DCM CMs, clathrin-mediated endocytosis (CME)-dependent signaling, may be recovered by EMP treatment in DCM TPM1-L185F iPSC-CMs, which supports that EMP modulates aspects of CME-signaling, and contributes to restored sarcomere functions.

Daria Plota, H. N. Saleem, K. Lin et al. · 0 citations

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