Author

K. Ligon

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Aug 2026

Tumor-tropic E. coli engineered as living T and NK cell engagers

LIME bridged effector and tumor cells, induced transcriptional programs of T cell activation, metabolism and proliferation, and enhanced cytotoxicity across cancer cell lines and patient-derived organoids, establishing LIME as a versatile living therapeutic platform for programmable, tumor-restricted immune orchestrati...

Shao-Bo Yang, Anna Clara Bader, S. Sendker et al. · bioRxiv · 0 citations

Open access Sep 2026

Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection

Findings define mechanisms by which tumors restrict targetable truncal truncal neoantigen display and suggest immunopeptidome shift strategies to circumvent immune escape.

Koji Haratani, Bruce R. Reinhold, J. Duke-Cohan et al. · Immunity · 1 citation

Open access Sep 2026

Heterogeneous and conserved radiation responses reveal FOXM1-dependent regulation of microcephaly genes in glioblastoma

Findings identify coordinated suppression of a FOXM1-associated MCPH program as part of the GBM radiation response, while suggesting that the radiosensitizing effects of pharmacological FOXM1inhibition extend beyond this transcriptional axis.

L. Van Eupen, E. Etlioglu, K. Tabury et al. · bioRxiv · 0 citations