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Open access Oct 2026

GCH1 p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations.

INTRODUCTION GCH1 has been implicated in Parkinson's disease (PD), but its risks variants and associations are not well defined. OBJECTIVES Our goal was to investigate the clinical relevance and PD risk associated with the GCH1 p.Ser80Asn variant. METHODS We first identified a segregating GCH1 p.Ser80Asn variant in...

Yi-Wen Tay, A. Lee, J. Schee et al. · 0 citations
Review Open access Oct 2026

Compound heterozygous and digenic inheritance in early-onset Parkinson’s disease: a systematic review

These findings support comprehensive detection of structural and sequence variants while highlighting the need for segregation, functional, and replication evidence to distinguish causal DI from modifier effects or coincidental variant co-occurrence.

V. Flores-Ocampo, G. Sevilla-Parra, Fang-Yuan Cao et al. · 0 citations

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