Jul 2026
Complex intra-host SARS-CoV-2 evolution following monoclonal antibody pre-exposure prophylaxis
K. Kamelian, D. Pascall, Meijun Cheng et al.
· medRxiv · 1 citation
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Jul 2026
Complex intra-host SARS-CoV-2 evolution following monoclonal antibody pre-exposure prophylaxis 2309595
Fixation of E340D abolished the surrogate defence provided by sotrovimab, eliminating neutralizing activity and exerting a positive epistatic effect on emerging mutations, which conferred the highest infectivity across all cell lines, with the most significant effect in low-TMPRSS2 cells.
K. Kamelian, D. Pascall, M. Cheng et al.
· Journal of Immunology · 0 citations