Author

K. Hutt

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Open access Oct 2026

GnRH antagonist-induced ovarian suppression does not protect the ovarian reserve from cyclophosphamide chemotherapy in tumour-bearing mice

Gonadotropin-releasing hormone (GnRH) analogues are used clinically to induce ovarian suppression during chemotherapy treatment and are proposed to protect the ovaries from chemotherapy-induced damage, yet their efficacy and underlying mechanisms remain uncertain. While most preclinical and clinical studies have fo...

Y. Lewis, Daniella Herszberg, Kate Fowler et al. · Frontiers in Endocrinology · 0 citations

Review Open access Jul 2026

Safeguarding the development of offspring: the role of genetic integrity of the maternal germline.

The role of maternal effect genes (MEGs) in orchestrating early zygotic development is explored, detailing their functions in epigenetic regulation, mitochondrial dynamics, DNA repair, and cell division, and the first comprehensive catalogue of associated diseases is presented.

Xuebi Cai, K. Hutt, Amy L. Winship et al. · Endocrine reviews · 0 citations