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The contribution of the gut microbiome to chronic heart failure (HF) remains poorly defined. We performed integrated microbiome and host multi-omic profiling of adults with chronic systolic HF due to nonischemic cardiomyopathy (n = 59) and healthy participants (n = 50), including longitudinal sampling in some cases. He...
It is shown that increasing PL levels in the outer leaflet or truncating LPS core oligosaccharides increases OM fluidity by disrupting LPS packing, and that reduced LPS abundance or disruption of divalent cation-mediated crosslinking primarily reduces OM stiffness with little effect on fluidity.
It is shown that XOS utilisation is strain specific among members of B. longum and highlighted how strain-level variation in carbohydrate metabolism may inform the design of targeted prebiotic and synbiotic strategies to promote gut health.
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