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K. Deisseroth

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Open access Jul 2026

AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo

This work developed genetically-encoded lysosome targeting chimeras (GELYTACs) that target circulating IgGs for clearance and degradation and establishes GELYTACs as a possible therapeutic modality that is deliverable using genetic medicine approaches.

J. L. Yang, K. Y. Loh, Cindy R. Sandoval Espinoza et al. · 0 citations

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