Background/Objectives: Cancer remains a major cause of mortality worldwide, and resistance to therapy continues to limit treatment success. Improving the susceptibility of cancer cells to immune-mediated killing, particularly by natural killer (NK) cells, may enhance therapeutic outcomes. This study aimed to determine...
Tanyarat Pianmak, A. Panya, Natthanich Boonsatit et al.· Pharmaceuticals· 0 citations
Colorectal cancer (CRC) is closely associated with chronic inflammation, and the NF-κB pathway acts as a central regulator of the inflammatory response that promotes tumor progression. In this study, we examined the anticancer and anti-inflammatory potential of anilino-1,4-naphthoquinone derivatives (compounds 3, 8, an...
Sakdiphong Punpai, Panupong Mahalapbutr, Panyakorn Taweechat et al.· Biochemistry and Biophysics...· 0 citations
Findings establish compound 12 as a promising lead candidate for the development of new anti-colorectal cancer agents and provide mechanistic insights into the interplay between COX-2 inhibition, inflammatory modulation, and apoptosis induction in inflammation-associated colorectal carcinogenesis.