Clinical dementia diagnosis requires substantial expertise and is complex and costly. Therefore, large population-based studies often lack gold-standard longitudinal diagnoses and instead use classification algorithms employing cognitive, functional, and health-related measures to identify dementia. We evaluated whethe...
Gina E. Nam, Jun-Xian Liu, Suhani Amin et al.· American Journal of Epidemio...· 0 citations
Frontotemporal lobar degeneration (FTLD), predominantly comprised of tau and TDP-43 proteinopathies, is a common cause of early-onset dementia. Biomarkers that reliably classify FTLD subtypes are limited, thereby hindering in-vivo diagnosis and clinical trial stratification. We conducted large-scale, multi-platform cer...
R. Saloner, L. Cornelis, Joshua Downer et al.· bioRxiv· 0 citations
It is shown that spontaneous menopause is characterized by dysregulation in inflammatory, synaptic, metabolic and Alzheimer's disease biologic processes, which tracked more strongly with hormones than with age.
Madeline Wood Alexander, Jennifer S. Rabin, Michelle R. Caunca et al.· Nature Medicine· 1 citation
Introduction: Frontotemporal lobar degeneration (FTLD) is a devastating disease that commonly results in early onset dementia, yet its rarity and heterogeneity limit large-scale research and clinical trials. Remote monitoring via low-burden digital health tools may overcome these barriers. We evaluated clinical utility...
E. Paolillo, Sreya Dhanam, J. Taylor et al.· medRxiv· 0 citations
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al.· Journal of the American Medi...· 5 citations
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