K. Aran

CARM1 as a therapeutic target: The future of disease-modifying therapies for epilepsy.

Epilepsy is a chronic neurological condition characterised by persistent or recurrent spontaneous seizures caused by aberrant and hyper-synchronisation of neurons. It is one of the leading causes of neurological problems affecting over 50 million people all around the globe, and at present, disease-modifying therapeuti...

Unraveling the role of FGF21 in epilepsy disease: mechanistic insights and therapeutic Potential

Postbiotics as a Therapeutic Target in Cognitive Impairment: Exploring into Molecular Pathways and Neuroprotective Effects.

A systematic evaluation of the role of postbiotics in the prevention and management of CI across different neurological and metabolic disorders is provided, and the available preclinical findings with potential therapeutic implications and future directions are summarized.

Postbiotics as a therapeutic frontier in Parkinson’s disease: Insights into molecular pathways and neuroprotective effects

Overall, postbiotics may represent a promising therapeutic strategy for targeting neurodegenerative processes in PD, although their safety, efficacy, optimal dosing, and clinical utility require further investigations.

Epitranscriptomic imprints on glial cell polarization: METTL3/IGF2BP2 axis as a driver of neurodegeneration in Alzheimer's disease.

New mechanistic truths of how m6A-dependent RNA regulation contributes to the progression of AD are compiled and therapeutic opportunities of METTL3/IGF2BP2 axis targeting for novel RNA-based therapies for neurodegenerative disease are discussed.

KLF4 in Parkinson’s Disease: Decoding the Molecular Puzzle of Neuroinflammation, Oxidative Stress, and Emerging Therapies

This review focuses on the potential molecular mechanism underlying KLF4-mediated neuroinflammation, oxidative stress, mitochondrial dysfunction, and apoptosis and targeting them appears to be a viable therapeutic strategy for treating PD.