Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been implicated in atherosclerosis and adverse cardiovascular outcomes, but prospective data on lower extremity arterial disease (LEAD) in Asian populations remain limited. We conducted a single-center prospective cohort study of 155 Thai patients...
N. Kulthamrongsri, Jutarop Phetcharaburanin, Supranee Phanthanawiboon et al.· Scientific Reports· 0 citations
Investigation of how neuronal ERO1L elevation reshapes cellular homeostasis before overt dysfunction in Drosophila melanogaster establishes a pre-symptomatic state in which proteostatic and metabolic adaptation coexists with early vulnerability of nuclear and RNA-homeostasis pathways, preceding overt oxidative stress a...
L. Lo Piccolo, Ranchana Yeewa, Puttachat Poound et al.· bioRxiv· 0 citations
This review synthesizes current mechanistic and translational evidence to conceptualize the gut microbiome as an organ‐like functional system, delineate its structural and functional organization, and propose a framework for mapping, modeling, and therapeutically targeting microbiome‐derived circuits to support precisi...
Yang Bi, Wei-Bin Song, Maria Glymenaki et al.· iMeta· 0 citations
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