Justine D. Mintern

Identification of active deubiquitinases in dendritic cells under unstimulated and activated conditions

Ubiquitination is a post-translational modification with well described roles in the regulation of immune cell function, such as dendritic cells (DCs). DCs are crucial initiators and regulators of T cell-mediated immune responses. In this study, we use activity-based probes and proteomics to systematically profile DUBs...