Author

Jürgen Jänes

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Open access Jul 2026

A Multi-Omics Framework Reveals Phosphorylation-Dependent Control of Protein Interactions

A nested linear regression model is applied to pan-cancer data from 1,006 tumours and reveals a widespread coupling between phosphorylation and interaction-dependent protein abundance and provides a prioritized, structure-informed resource for characterizing the human phosphoproteome.

Kosuke Ogata, Emmanuel Matabaro, E. Aarts et al. · bioRxiv · 0 citations

Open access Jul 2026

Capabilities, specificity gaps and training-data dependence of AlphaFold3 across diverse application areas

It is found that, while AF3 can perform well in favourable settings, this performance is uneven across applications and its predictions and use of confidence metrics will depend strongly on the specific application area and must be interpreted with respect to training-set overlap.

O. Follonier, Yan Liu, Pablo Campomanes et al. · bioRxiv · 1 citation