Author

Junyi Chen

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Jul 2026

Surface-Confinement Effect Enables Bioorthogonal Drug Release in Tumors.

This work covalently tethers prodrugs to the Hf-nMOLs surface, and constructed two-dimensional nanoreactors that spatially localize the activation process within an interface enriched with reactive species, presenting a versatile strategy for robust radio-chemotherapeutic combinations, achieving the simultaneous releas...

Zhiyu Tu, Ziyang Sang, Yang Xu et al. · Journal of the American Chem... · 0 citations

Aug 2026

A Bioorthogonal Desilylation System Potentiates mRNA Therapeutics in Tumors.

This work presents a metabolically targeted, bioorthogonal-activated delivery strategy to address the selectivity and efficiency limitations of current mRNA medicines, providing a promising platform for precision oncology.

Ming-Zhe Zhang, Chun-Hong Wang, Xiaohan Xu et al. · Journal of the American Chem... · 0 citations

#protein folding Open access Aug 2026

A binding-to-release strategy for targeted anticancer drug delivery.

A framework that overcomes the internalization barrier, broadening the target scope for therapeutic and diagnostic conjugates is established and extended BTR to programmed cell death ligand 1 (PD-L1) and an mRNA-display-derived FAP peptide, suggesting potential broad applicability.

Zihao Wen, Mengxin Xu, Zi-Jun Yan et al. · Nature · 1 citation