Prion disease is delayed in mice overexpressing sortilin following prion infection
Conformational conversion of the cellular isoform of prion protein, designated PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , plays a key pathogenic role in prion diseases, including Creutzfeldt-Jacob disease in humans. We previously reported that sortilin, a member of the vacuolar protein sorting...
Batzaya Batchuluun, Hironori Miyata, Nandita Rani Das et al.
· Scientific Reports · 0 citations