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Junhyeong Lee

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Open access Sep 2026

DeepU-PRS: nonlinear and uncertainty-aware SNP heritability modeling for annotation-informed polygenic risk scoring

Abstract Polygenic risk scores (PRSs) are widely used to quantify genetic predisposition to complex traits, and their predictive accuracy can be enhanced by incorporating functional annotations into single-nucleotide polymorphism (SNP) effect-size estimation. Existing approaches typically assume linear relationships be...

Junhyeong Lee, Dokyoon Kim, Seunggeun Lee · 0 citations

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