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Jung-Chun Chu

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Open access Oct 2026

Optimisation and mechanistic characterization of a selective benzoxazine-based MAP4K4 inhibitor in pancreatic cancer cells

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with limited targeted therapeutic options. Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) has been implicated in PDAC progression, but the development of effective MAP4K4 inhibitors requires further improvement in potency, se...

Yi-Wen Wu, Chun-Lin Yang, Yu-Ting Fang-Chin et al. · 0 citations

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