Junde Xu

Exploring the Alignment of Generation and Understanding in Protein Structure Modeling

Understanding and generation are often treated as two separate paradigms in training deep neural networks, despite the fact that both are trained with closely related objectives such as denoising and masked prediction. While prior studies have shown that generative models often learn suboptimal representations for unde...

CatESO: Differentiable Enzyme Sequence Optimization Guided by Substrate-Aware kcat Prediction