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Author

Jun Zhang

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Review Open access 2026

Engineering intramolecular adjuvants for next-generation vaccines

Vaccines play a pivotal role in reducing the global burden of infectious diseases. Currently, vaccine development is transitioning from empirical approaches toward precision engineering. The intramolecular adjuvant strategy, which fuses adjuvants and antigens into single molecules via genetic engineering, emerges as a...

Ye-Tong Wang, Wei-Nian Liao, Zhi-Ling Zhang et al. · 0 citations
Open access Sep 2026

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

It is revealed that regulatory T cells within the bone marrow microenvironment actively safeguard the survival of aged HSCs via a previously uncharacterized signaling pathway, and targeted BIRC6 inhibition in HSCs using antibody-conjugated lipid nanoparticle-encapsulated antisense oligonucleotides (LNP-ASOs) significan...

Wei-Nian Liao, Fang-Ze Shao, Shao-Yan Wang et al. · 0 citations
#protein folding Aug 2026

Oligomerized receptor binding domain blocks pan-sarbecovirus infection via enhanced avidity to host receptor.

HRBD demonstrated potent and broad-spectrum inhibition against Pangolin-CoV, SARS-CoV, SARS-CoV, SARS-CoV-2, and its variants, lowering the half-maximal inhibitory concentration (IC50) by approximately 1000-fold compared to the monomeric RBD.

Jintao Zou, Lingyu Su, Jian-Sheng Lu et al. · 0 citations

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