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Jun-Yan Peng

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Open access Oct 2026

A Mir338-CDK8-mitochondrial axis governs lineage-specific osteogenesis and defines Runx2 pleiotropy in cranial sutures.

The paradox of Runx2 pleiotropy is resolved by bridging positional identity, mitochondrial metabolism, and miRNA-mediated regulation, offering a redefined conceptual framework for understanding developmental processes and informing precision therapeutic strategies for congenital skeletal disorders.

Han-Shu Zhang, Xue-Ying Ma, Jun-Yan Peng et al. · 0 citations

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