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Author

Jun Xian

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2 papers indexed here

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Sep 2026

Hypericin attenuates pathological scarring through concurrent modulation of transforming growth factor-β1 and bone morphogenetic protein 2 signaling in vitro and in vivo.

BACKGROUND Pathological scarring is driven by persistent crosstalk between profibrotic cytokine signaling and extracellular matrix remodeling. Transforming growth factor-β1 (TGF-β1)/Smad2/3 signaling broadly activates fibroblasts, whereas bone morphogenetic protein 2 (BMP2)/Smad1/5/9 signaling reinforces matrix-produci...

Yangmeihui Wang, Jun Xian, Shu-Ya Ren et al. · 0 citations
Sep 2026

MDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation.

Topical MDL800 improved gross photoaging-like changes, reduced epidermal thickening, preserved dermal collagen organization, and ameliorated associated molecular alterations in both cellular and animal models, and exerted protective effects against UV-induced skin photoaging.

Shu-Ya Ren, Si-Jie Zhou, Guo-Cai Xu et al. · 0 citations

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