Author

Jun-Xia An

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Open access Oct 2026

Bakuchiol perturbs purine metabolism and ABC transporter pathways in Streptococcus agalactiae, possibly affecting S. agalactiae-induced mastitis

To evaluate the bacteriostatic effect of Bakuchiol (Bak) against Streptococcus agalactiae , explored its antibacterial mechanism in vitro , and investigated its in-vivo therapeutic activity in a mouse mastitis model. The Oxford cup assay was performed to test its inhibitory activity on S. agalac...

Rui Wang, Ya-Rui Jin, Wei-Qi Jiang et al. · Frontiers in Microbiology · 0 citations

Open access Aug 2026

Kurarinone and sophoraflavanone G from Sophora flavescens suppress Streptococcus agalactiae biofilm via dual antibiofilm mechanisms involving adhesion protein binding and ABC transporter pathway perturbation

Introduction Biofilm formation by Streptococcus agalactiae (S. agalactiae) is a major driver of chronic bovine mastitis that resists conventional antibiotic treatment, yet targeted strategies that disarm its biofilm machinery remain limited. Sophora flavescens (S. flavescens) is a medicinal plant rich in prenylated fla...

Ji-Hao Shi, Yun Zhang, Jun-Xia An et al. · Frontiers in Microbiology · 0 citations