Jun Wu

Berberine ameliorates thioacetamide-induced liver injury in zebrafish through PPARγ signaling and restores bile acid homeostasis

Ethnopharmacological Relevance Coptis chinensis Franch. (Huanglian), a traditional Chinese medicinal herb used for “heat” and “dampness” syndromes, is clinically associated with metabolic disorders such as NAFLD. Berberine (BBR), its major bioactive alkaloid, has shown metabolic benefits, though its mechanistic basis i...